For Alphabet (Google) the revenue distribution from 2015 to 2021 was approximately 33% for all of Europe, Middle-east, and Africa. It's unclear to me the actual European numbers since they are combined EMEA.
For Apple in 2021 the revenue was approximately 23% for Europe (no middle-east or Africa).
For Facebook in 2021 the revenue was also approximately 23% for Europe (no middle-east or Africa).
So it's safe to say that a first offense would potential halve the revenue for the region, and a second offense would remove the financial rationale of doing business in the region.