>In other words, there are thousands of papers supporting beta-amyloid and/or building off the data / theory.
It is important to note that the fraud doesn't encompass all of beta-amyloid, but is specific to a subtype called Ab*56.
The plaques are there in autopsy tissue. We can see them. What is causing them is still uncertain.
>No, in reality, this should indicate there is systemic fraud in the industry.
Disagree. This indicates that the field can successfully identify and remove bad/fraudulent lines of inquiry in a relatively short amount of time (a decade).
>A complete overhaul is needed
This is extreme. Fraud happens. Scientific process is designed to root out unverifiable theories, by design. The process is working as intended, why burn it down?