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This possible, but the profit margins that exist in the illegal drug business would not be replaced. Their smuggling networks & personnel would become a massive financial burden (how long it would take for that financial burden to destroy them is a separate issue.)

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If we assume drug lords are in it for the money and/or power they'd cut their losses ASAP.

For any of them that are really in it for the thrills the time would depend on their reserves, but I doubt it'd last longer than a few months for any of them.

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