It can be incredibly draining. I think it's important to also have boundaries and know how to "pick your battles". Some people are unwilling or unable to open themselves up by being sincere, having a genuine discussion can leave people feeling vulnerable and there's a level of trust and willingness to take a risk necessary to truly have a deep discussion about certain topics.

Sometimes it's just not possible. Some people have impenetrable barriers they will defend with no regard for how they do so and the way it affects others.

That being said I like to think of it like I'm reaching out to someone, and often they don't reach back, in a majority of cases they don't want that contact. Those times when someone does, though, brings me great hope.