Estrogen is a 'stress hormone' that needs to be balanced with anti-stress hormones for optimal health.

All the steroids in the body are made from cholesterol. The term is steroidogenesis: https://en.wikipedia.org/wiki/Steroid#Steroidogenesis

Estrogen is at the end of the steroidogenesis pathway. It's a stress hormone. In the menstrual cycle, estrogen tells the uterine lining to 'swell and divide'. Fertile women are protected from their higher estrogen levels by their high levels of Progesterone USP during the luteal phase of their menstrual cycle. When women reach menopause, their heart attack numbers rapidly reach men's heart attack numbers.

Adipose tissue has a lot of the aromatase enzyme [0], which converts testosterone to estrogen. People with more adipose tissue lose their testosterone by converting it to estrogen. The heart of both genders concentrates testosterone.

[0] https://en.wikipedia.org/wiki/Aromatase

[1] Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension - https://journals.sagepub.com/doi/full/10.1177/20458940209520...

I sold a progesterone supplement on Amazon years ago... My best customer was "Billie", who I suspect was MTF and was using progesterone USP to balance his estrogen treatments. I referred him to other manufacturers when he noticed my supplement was no longer available.

Pregnenolone is a useful supplement for balancing the steroid system: https://en.wikipedia.org/wiki/Steroid#/media/File:Steroidoge...

(edit: added [1])