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The best way to use Nix in MacOS is through qemu and utm in my opinion.

Then again, I don't like much about macs except the touchpad and macOS annoys me.

So this advice might not hold as true if you actually like OSX. Maybe checkout:

I'd also advice using flakes to simplify a lot of this.

I agree. I've mentioned this elsewhere in this thread, but I just wanted to second that I've found running nixos as a vm through UTM has been a flawless experience for me. I have a fairly complicated setup for a bunch of different machines that I am able to manage through one flake. I have no desire to ever go back to a not-fully-declarative setup again.

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