That's such an awesome use case! Do you have any examples you can share?
The originals look like malformed mutants at 256x256 with nonsensical key bits and strange twisted handles.
Note that this does not replace a good pixel art artist either - for things like walls, anything that needs to connect together or tile like a dungeon wall or castle, or a cohesive art style, this will not do. But for rapidly identifiable different quest item drops it's not terrible.