While porting 6 jQuery plugins over, I encountered various differences in the APIs and it was a bit of a headache to sort through them (especially the very subtle differences), but it was worth it.I'm writing a blog post currently on my porting experience, as I imagine others might take on the task and encounter similar issues.
For people comparing Zepto to this offering, keep in mind that Zepto also offers mobile-specific events, so if your reason for porting is mobile latency, Zepto's a good bet.