From Apple's Lockdown site, it's hard to tell the extent of what is locked down.
> Web browsing: Certain complex web technologies, like just-in-time (JIT) JavaScript compilation, are disabled unless the user excludes a trusted site from Lockdown Mode
This is allegedly the fix for this exploit for webkit: https://github.com/WebKit/WebKit/pull/3023, it appears to at least somewhat related to the JIT, but I don't know enough about the exploit, or webkit to make that determination.
Sounds pretty serious, has active exploitation like this happened before in the Apple ecosystem or is this like most zerodays; edge cases and state level exploits that don't target broadly?