Or it could be something like the Hawthorne Effect where the effectiveness is because the group knew they were receiving an experimental treatment.
Popular with ravers because they’re easier to handle on the dance floor.
It would be interesting to identify drugs that behave in this way and use them as comparators.
The doses of benadryl they were giving them as an "active placebo" are approaching levels where you do start to get some... Interesting (and often extremely distressing) deliriant effects.
0/10 would not recommend tripping on benadryl,