However, being perfectly in tune is also a big red herring kind of thing. People, especially people who like seeing math in music, get obsessed with chasing ideas of perfection in music and music is art... it isn't supposed to be perfect. To have sounds at perfect intervals or sounds perfectly in tune is after a certain point just an annoying detail compared to literally every other aspect of a piece of music.
A lot of advanced digital synthesizers will carefully detune oscillators from each other so they aren't "perfectly in tune" in order to get thicker sounds.