It's clear he can do it: the ending of Anathem ties up everything very neatly and it is hard for me to imagine any major events happening in the characters' lifetimes that would rival the plot arc they've been through.
It's still my favorite Stephenson novel though.
Minor spoilers:
I loved the world-building and mystery in the first half, the main character lives in a post-apoc monastary, tons of great details and tidbits. It felt vibrant, deep, reminded me of Redwall and the 5th Harry Potter, with the sexual repression and small-scale rebellion against authority.
He leaves the walls in the second half and stuff happens, I forgot most of it. The journey part felt like an afterthought. Something something aliens, really didn't feel earned or connected.
Anyway I do like the book, but the ending wraps up very abruptly thanks to the employment of this gimmick.