I’ve been programming ~15 years, and from my perspective, those frameworks helped us move on from a world riddled with XSS, “better than fail whale”-level reliability expectations, and software ossification (Gmail, Facebook, etc).
Today, the frameworks bite me in the ass about once a week, but I think it’s worth it to get safe React with strict TypeScript, and plenty besides.
Caveat: All infrastructure requires a lot of maintenance, though! YAGNI still applies, and hopefully you have (or are on) a team dedicated to supporting the tools that you do need.