I've talked to many React engineers and none of them have a good reason to use a library like Preact.
Once again, the author is content to reinvent the wheel unnecessarily and publish it as something that can/should be used in production. It's a useful toy, a nice exercise in "what can be done" but not much else. Yes, I'm aware of the countless "useless" things that get posted to HN all the time - none of them purport themselves to being anything more than what they are.
I have never met anyone with any sense using Preact, and I see no compelling reason to use Signals either when there are countless other libraries doing similar things, with developers that actually use them.