to maximize efficiency and cost savings is an AC-to-12VDC power supply boxActually, no. That power supply box contains an AC-to-DC rectifier, followed by a DC-to-DC power convertor: high-frequency convertors are much more efficient than 50Hz transformers and can be built with much smaller components than a toroidal transformer. Yes, you don't want 5V power lines in your walls, but 150V DC would still be more efficient for most devices than 120V AC.
The reason (other than inertia) why we probably won't do that is because of polarity: AC plugs can be inserted either way; DC plugs might destroy the equipment if inserted the wrong way, and most existing plugs allow both orientations. Not sure many people would like to "re-learn" how to insert a power plug.
But, truth be told, I have been thinking about getting myself certified as an electrical engineer so I can install DC voltage lines in my home: I already have DC solar panels (48V), and DC line batteries. It's awfully wasteful to have AC convertors on them all, just because that's the standard we've settled on.