Its time for some Zachtronics game to make the migration. If Factorio can happen, then I would think the Zachtronics games can do it too (performance wise).
Agreed with the sibling comment that Opus Magnum seems like it'd be a good fit. But the economics of a port may not make sense. Infinifactory was Unity, while Opus Magnum and most (all?) of the other 2D games use a custom engine.
Zachtronics stopping game production is a painful loss.
But the iOS store is much harder to just “fire and forget” on.