I know nothing about the Java ecosystem. Isn't Clojure supposed to be compatible with the JVM and everything that runs of top of it?
But in order to do that, it does some interesting things under the hood, and it doesn't play nicely with reflection by default (amongst other things). For some non-Java JVM languages that's a major problem since their compiler produces JVM byte code that relies heavily on reflection (Groovy is/was a great example of this). I'm unsure how much, if any, reflection Clojure relies on but that would be the most likely reason for it to struggle with GraalVM compatibility.