Drug Turns Cancer Gene into ‘Eat Me’ Flag for Immune System

Amgen must be happy. KRAS inhibitors have been a recent target recently, notably for NSCLC: https://en.wikipedia.org/wiki/Sotorasib

I should note that not all cancer cells exhibit KRAS mutations, so if this ARS1620 can get cancer cells to express more KRAS mutations (if biopsy shows KRAS mutations exist), now we have something to target.

Reminds me of other therapies that need some type of expression on the cancer cells to enhance inhibotrs, like using the cowpea mosaic virus, TROP2, PIK3 expressions. I think this is where immunotherapy is going next, to take an expression, force cells to over express it (specific mutations that healthy cells rarely have), then bind inhibitors to target the cell for apoptosis.

https://ucsdnews.ucsd.edu/pressrelease/researchers-shed-ligh...

https://en.wikipedia.org/wiki/Phosphoinositide_3-kinase_inhi...

If someone has a lung tumor and the immune system is coaxed into killing/eating the cancerous cells, what happens after that? Is the lung able to fill in the gap with new healthy cells, or can the patient end up with a big hole in their lung?

Many researchers have tried for many years to find a drug for cancer, but I believe no one has succeeded. They treat only early-stage cancer patients who are surviving, but many patients who are not diagnosed in the early stages are not surviving. I hope this is useful for all patients at all stages. Thank you, God and researchers.