Unless I'm missing something, I think I plan to just run this all the time. I see very few downsides, personally.

> web fonts might not be displayed

Great, I almost always prefer system default fonts.

> Incoming FaceTime calls are blocked

Perfect, I don't use it, it is always some scammer.

> Incoming invitations for Apple Services

Perfect, I don't care.

> Shared albums are removed from the Photos app

I don't use this stuff, I don't care.

> To connect your device to a USB accessory or another computer, the device needs to be unlocked.

This seems like it should have always been the default.

> Configuration profiles can’t be installed

Perfect, nobody should be trying to manage my phone.