0.13 ms per request is
loads when you consider a typical web page (facebook homepage) has about 700 requests now, and due to the single-threaded nature of javascript they all need to be processed sequentially. Ie. thats 91 milliseconds seconds of pegging one core, just for one extension, for loading one page.
It's also probably an underestimate, because it doesn't include the IPC time within Chrome, which involves at least two context switches, and the associated cache rewarming.
Granted, extensions could be better implemented - for example, for URL blocking, there should be a bloom filter for allowing stuff so that the whole list doesn't need to be checked.