For example, if society moved in a way that rewarded behaviour that would have been considered pathological in the past, would those people who cared enough to actively resist the tendency be more likely to be deemed mentally ill?
I know psych was weaponized like this in communist countries, but I can imagine it happening more pervasively and organically in democracies, from the bottom up.
Back to your point, instead of eg anxiety being something disordered, maybe it’s a normal expression of human behaviour but in a world where the opposite traits are rewarded. Maybe 500 years ago or 100 years hence, the anxious are normal and confident optimism will be pathologized.
However, high functioning autism or mild schizotypal/schizoid disorders probably would not be debilitating unless the society had a low tolerance for eccentricity.