In a room where participants are verified with each other, you'd be warned of this with a loud red shield with an exclamation mark in the room header. Additionally, if you're extra worried about a room, there's a "Never send encrypted messages to unverified sessions in this room from this session" setting you can flip in the Element clients.
That said, this can and will be improved in the future, by signing room state events and implementing TOFU (trust-on-first-use) for user identities, so that you can have a large amount of protection even before you perform manual verification with other users.