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Wow, that's certainly a novel way to disseminate technical information. I could not stand it, and I'm not very dismissive of geek content.

The live anime avatar and high-pitched vocal conversion are... idiosyncratic, to say the least

Is there software that does this? Or is it custom made?

She's using https://inochi2d.com

Which she contributed to, so I guess the answer is... Yes.

I really like the work being done on this project and I want to keep up, but the voice is like nails on a chalkboard to me. I can't listen to more than two seconds without closing.

cant watch, that avatars voice is just simply plain annoying. Sorry.