Spiral is an interesting use case of FME for database fetching that just popped up, https://usespiral.com/
General FME computation is obviously not likely to be practical or cost effective any time soon, but there may be some specific use cases, like querying a database, where hiding the information you want to know from the server is advantageous. There are adversarial environments where knowing the information your adversary is interested in provides a competitive edge.
I'm curious to dig more into their implementation.