I like deno.com, but I am deeply suspicious of their speed test methodology. I hope I am wrong, but it really looks like they are comparing time-to-first-byte (TTFB) including TLS, i.e. a 'cold start'. It should not be almost 400 ms from Amsterdam to Virginia on an existing connection.

If your app makes one and only one connection, then fair enough, that is a real penalty. Otherwise, this is just the benefit of literally every single CDN. With enough traffic, their edge servers will keep connections open to origin.

For serverless, there is no origin -- even better for performance, assuming it has no need for a common data store.