* Program increment planning is absolutely painful. Three full days of meetings, and rarely do the stakeholders come with fully refined features. And, typically, what plan emerges is changed within two weeks because of emergencies or an executive seeing a shiny bauble we absolutely need to have.
* Two week sprints seem too short, at least for a group working in a highly regulated industry that requires a ton of manual testing and paperwork. I will also admit that we likely have trouble writing appropriately sized stories, but part of that circles back to the need for massive validation efforts.
* We suffer from lots of turnover in product management (and perhaps too many product managers). If a PM leaves, their features tend to die on the vine, even if some executive has decided they are important. That leaves us with a massive backlog.