Wikipedia says:
"The loss of the population [due to disease] was so high that it was partially responsible for the myth of the Americas as "virgin wilderness". By the time significant European colonization was underway, native populations had already been reduced by 90%. This resulted in settlements vanishing and cultivated fields being abandoned. Since forests were recovering, the colonists had an impression of a land that was an untamed wilderness."
https://en.wikipedia.org/wiki/Native_American_disease_and_ep...