I literally just spent some time this weekend trying to get it working with a dnsresolver locally routing my home network there and then out to nextdns, all through tailscale. The issue really came down to something I didn't bother diagnosing, and very well could've been my router.

But. This just solved all those issues. Threw my nextdns address into tailscale and away i go. I swear every single time I run into some modern inconvenience of the web Tailscale (by mission statement) is there to solve it.