The thing to understand early these days is COGS and whether the business can scale its service with good margins. That is a significant change of concerns for investors from the past years where growth was the only thing that mattered.
The other thing that I think is a little off in this post is the idea that startups not caring about costs are a big driver of hyperscaler revenue. I suppose that may have been true a few years ago but AWS, Azure, and to some extent GCP are having a lot of success moving legacy on-prem deployments to the cloud. It's not uncommon to encounter 50 year old enterprises with a billion dollars of cloud spend. One example of this is the dedicated SAP instances that AWS has, some of which cost $100K per month.