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Places where you want to auto-generate html reports or do simple data processing into html and not fuss over basic inline styles.

I have a few internal tools that use https://newcss.net/ and it is just a nice tool to have in your quiver.

Extremely simple static site generation (like Grandma used to bake in the 90s web). Either by hand with minimalist HTML or just taking the output directly from almost any Markdown/reStructuredText/Asciidoc/etc processor and generally only needing to add a single LINK tag at the top to one of these CSS files.

you can switch between them without altering the html

Easy to toss on content like markdown or straight out of a CMS and get nice looking pages vs. the default browser styles (that look like 1996).