They'll say that the room type offered on the OTA is different than the room type booked direct - even if it's the same room.
I stayed at the Kimpton Epic Miami. Paid almost $150/nt less through Priceline. Tried to use IHG's Best Price Guarantee and they said it's a different class of room.
$465/nt through IHG - https://i.imgur.com/nTdZTnM.png
$342/nt through Priceline - https://i.imgur.com/3jabBss.png
There's a lot of misinformation in this thread.