> Right, because which blade half is on the bottom affects which direction you need to apply force so the blades meet tightly.
That would violate Newton's Third Law of motion, so no.
You don't have to apply force in any different direction if you put scissors with symmetric handles in the wrong hand. You will, however, end up tilting the scissors to the side so that you can see what you're doing. But that's not the same as needing to apply force any differently. It's a required sight issue not a required force issue. Anything else only comes from handle shape.
If the scissors don't have ergonomically sloped handles, an ambidextrous person can comfortably cut with either hand if they don't look at what they're doing.