For gaming or videos I actually can’t tell the difference between 4K and 1440p. For text rendering I absolutely can.
A common video subsampling setup is 4:2:0.
https://en.wikipedia.org/wiki/Chroma_subsampling
In addition, common video compression techniques (at least the simple ones that I could still understand) basically reconstruct blocks of pixels. Reconstruction is lossy, at best.
If I had to guess, something similar could be done in games as part of their optimizations.