Medium confidence is often close enough that you can formulate a hypothesis, but high confidence still isn't close enough that you'd stake millions of dollars of experiments on it anyways. Most of the people in structural biology in pharma that I have chatted with said they're still solving the structures of their targets even with high-confidence AlphaFold models.

For me, as someone solving structures on a monthly basis, AlphaFold is great because after I get back my electron density map, I dump my sequence into AlphaFold, get a model (of any confidence) and most of it fits well enough into my density map that I don't have to start trying to model from nothing, and it saves me honestly days of work.