If your asteroid is only 20 to maybe 400 meters across, having it land somewhere absurdly remote on land or far off into the deep oceans would minimize harm, but for asteroids much bigger than that (and even 400 meters is really stretching the bounds of acceptable size), it doesn't really matter where the impact happens, millions or more people will almost certainly die.
If you scale up to a size of, say, 900 meters or larger, then you're talking global multi-year catastrophe no matter where the impact is.
If you then scale up to over a mile or two in diameter, then you're talking global multi-decade cataclysm no matter where the impact site is.
So yeah, even with Siberia, the Canadian North, Antarctica, the Sahara or the central pacific ocean. Any size beyond a few hundred meters makes specifics not so important in terms of death toll and major climate effects.