For example, the refrigerant R-410A does about 2000 more greenhouse warming over a 100 year period. So a leak of 1 kg of R-410A is equivalent to about 2 metric tons of CO2 emissions.
10 years ago I bought an expensive tumble drier with a heap pump in order to be nice to the environment. After a few years there was an issue with it and I called a repairman. He vented the refrigerant and refilled it as part of his repair.
My calculation said it was an equivalent emission of about 1300kg CO2. Environmental impact immediately went negative.
This will be an issue when everyone is heating their house with heat pumps. They are amazing, but you have to follow the rules when repairing and scrapping them.