The part at the end where he says they will listen is huge. Never underestimate how much someone simply listening can really help. Also, talking to a sympathetic stranger is often more helpful or even easier than talking to someone you know.
I always wondered why so many people around here get to feeling this way and I've narrowed it down to a few things. First, startups are hard, they're often lonely, and burnout can creep up on you without you noticing. Burnout can really make you feel worthless. Then there are those who feel inadequate because they're reading all these stories about successful and smart people solving hard problems and making it big while they feel small, stupid, and inconsequential. There's a strong success bias in the submissions here and other places people like us peruse which can lead to strong feelings of worthlessness and self doubt.
I've been there and I understand so well all of these things. I often wish I had a clone that just repeated what I tell myself whenever my negative voice starts nagging: Baby steps, you can't know it all or be it all and you certainly can't conquer the world in a week. No matter what anyone else is saying or doing out there, in the end we're all human, we're all going through the same things and we all feel the same way at one point or another. It gets better.
Thanks for writing this and extra thanks for including those toll free lines.