"Humble Bundle games always work on Windows, Mac, and Linux"
The experience of the mono-compiled Atom Zombie Smasher (from Bundle 1 or 2 IIRC) was pretty poor on Linux.
Never got to play it myself - I saw it mentioned that it was easier to get it running using wine + the windows installer (including all the faffing about with dotnet under wine) than natively. Might try that this weekend.
All other bundle titles I have played run well, apart from the occasional dual head quirk (though I am more likely to blame nvidia's poor randr support for that)