This is a tough seat to go after because it's a reliable Republican district (around 2/3) and Smith has held his seat since way back in 1986. He's extremely entrenched, so the Republicans aren't going to be particularly tolerant of a challenger (edit: in the Primary), and the Democrats probably can't win the district.

I'm not sure who exactly lives in that weirdly-outlined subset of Austin, but unless something dramatic has changed since I lived there, his segment of San Antonio is dominated by traditionalist Chamber of Commerce types. His chunk of Austin might be an exception, but I would expect it will be pretty hard to get much traction in the rest of his district based on tech issues.