I would interpret it as "don't put your life on hold". Life is all relative, so when you compare stuff, you compare it to what you know. Getting married and having my daughter (currently 1yr) has given me something amazing to compare everything else I do to.

So, I'm still just as hungry to create "the next big thing" but if it doesn't happen, fine, I already got the top prize.

I guess the irony is that my pursuit of "the next big thing" is so that one day I can spend more time with my wife and daughter, but actually it's currently having the exact opposite effect...

Because life is finite and relentless. Because it's better to take opportunity before it's gone forever. Because some things take two, and if you don't go all in in time the other will move on, n'er to return. Because better to have loved and lost than never to have loved at all. Because procreation is awesome. Because not procreating, ever, is (for most) an emotional black hole. Because your business doesn't give a damn about you, but your spouse always will.

Because my daughter lying in front of me pestering me to play a game is the best thing ever, better than any technological or business success - and I'd best get to playing that game now.

And (game now over) because, when she's just 3 months old, having a doctor wonder why you're still alive and whether you will be a week hence, the indescribable melancholy will be about her and her mother, not about whether a project was finished.