Not full, but anything that is not easily replaceable. My documents, code, photos & videos, ete. This sort of stuff is on at least two providers as well as any original copies or copies synced/cached on other devices. And one of the backups is "soft offline" to ward against malicious tampering taking out everything (originals, backups, synced copies) in one swoop. A small selection of things (keepass db, a few legal documents, …) get the full offline backup treatment.

Anything I'm only keeping for convenience or sending cloudwards for transfer/sharing purposes, doesn't need the extra protection. Though it sometimes gets it as errors in that direction are better than risking failing not-safe with other data.