Yes, it absolutely is. Ads not only cost me my time and attention, but also consume resources (network bandwith, CPU time, screen real estate) that I might not want to be consumed. Just open any consumer-oriented webpage these days, and I can guarantee you will get 2-3 videos (!) or animations autoplay immediately, and a large part of your screen eaten by "garbage". Sometimes reader mode helps, sometimes it does not...
One thing that I usually do is when a page shows an explicit ask to turn my adblocker off, I close that page. This is fair enough, you can call this a transaction, and I can opt out of it.