If you are planning to Vegas, you gonna have problems on SR-152/I-580 to I-5. Also, expect problems on SR-58 between Bakersfield and Barstow on I-15. Even if you want to go to Sacramento, expect long delays on all routes.
Whichever freeway you pick, you will have problems: bad visibility, very slow traffic, partial closures due to puddles, complete closures due to floods (like the north of SFO airport last time).
That's why CHP, Caltrans, NWS advise people to postpone their travel unless extremely necessary. No storm tourism either.