Also! You may find this Twitter very interesting as well.... ;P https://mobile.twitter.com/justsaysinrats?lang=en
(And good point on the K-hole, in completely naive users my understanding is that this would likely induce a K-hole under IV conditions, but also we have to remember there are dose curve spike flattenings that happen depending upon dosing delivery methods due to transporter saturation, for example, etc as well....)
My wife is 5'7" (170cm) and weighs 125 lbs (57kg), and takes 150mg five nights a week. That is about 2.6mg/kg. When she first started taking it the only side effect was on occasion she'd get double vision. Twice in a year she has had a night where it hits hard and she needs me to set with her because the disassociative aspect is unsettling to her. 99% of the time, though, she said it is like being mildly drunk, like after a glass of wine or two, nowhere near k-hole territory.
She has no other experience (recreational or therapeutically) with psychedelics/disassociatives. Perhaps the antidepressant she is taking dampens the effect of the ketamine.
All in all, she is glad to have the antidepressants, but there has been no silver bullet. It is always lurking just below the surface and she is constantly aware/afraid that it will resurface in full force.
Also PSA ket should probably not be taken orally as it will damage your bladder (it always does but I think oral ingestion is worse for this)
Oral has the least bioavailability, but unless one is taking dangerous doses what I've heard is it doesn't likely matter. People will lose so much more in the dosing runaway spiral than from administration method -- you're going to reach a stable point either way if you're holding a certain dose, I believe. I've heard oral is less than ideal for trying to maximize dose response time and efficiency for amount-taken, but IM for example even far outstrips oral or nasal (once again, as implied earlier, I only recommend and advocate for appropriately medically prescribed and dosed Ketamine.
Edit: also a bit of a wtf after the fact but who the heck is taking Ketamine subcutaneously? On first blush, that sounds certainly nightmarish compared to any of the other injection methods.
I'd like some data to support this.
My understanding is you're going to pee it out (or pee out the waste products from it) one way or another. Oral dosage lasts longer, so theoretically the time it spends entering your bladder is longer, but I don't see why it would be that much of a difference.
The main issue with oral usage is that it's much weaker, you need to take much more for similar effects.
But insufflation damages your nose and sense of smell, so oral is my preferred method.
I've never heard of taking it subcutaneously. I'd plug it long before I'd try that
And yes, the deal is you have to take more orally than any other method. More material = more bladder damage.