2-monitor setups suck. If I had to go multi, I'd always go with an odd number of monitors (so, 3 or 5) to avoid assymetry. With 2 monitors, your secondary monitor is going to be placed either to the left or to the right of your primary, thus creating assymetrical workload on your neck muscles, affecting your health long term.
The only exception from this rule is a layout where your primary screen sits in front of you, and your secondary is placed beside it but rotated 90 degrees (to vertical position) and used mostly for placing various toolbars to declutter the main one. I tried this setup once and it worked ok ish for me. It looks weird but is quite practical once you get used to it.