I know that you are trying to make a point, but I think meth would be a viable treatment option for some people. Medically supervised and monitored. If you need to lose 100 lbs, it might be worth the other tradeoffs. For a short period of time.
Stimulant medications have been and still are sometimes indicated in Binge Eating Disorder.
It is actually prescribed sometimes.
I think surgically removing parts of your organs is more extreme frankly.