Disagree.
> who consume 50% of their diets in sugar (e.g. the Hadza)
"Their diet is made up almost exclusively of food that they forage on the forest and includes fiber rich and highly nutritious berries, bananas and honey while any meat they eat is hunted and caught wild." (https://healthyfocus.org/the-hadza-diet-and-the-key-to-a-hea...)
They don't eat sugar. Fruits & vegetables with lots of fiber, wild game. Nothing like westerners diet ... so not really comparable, imho.
"... the Inuit's bodies have adapted to better handle the process of gluconeogenesis, in which the body turns fat and protein into useable glucose. The Inuit have larger livers and a larger volume of urine than the average human, which helps their bodies to process the byproducts of their diet." (https://oureverydaylife.com/486115-the-inuit-diet.html)
Also ... not applicable to a typical westerner.
> The problem is not the food. The problem is obesity.
The food is the problem.
Eat whole foods, mostly plants, minumum fats & sugar, and obesity is problem no more.
> the development of GLP-1 agonists has maybe cost $20 billion
What's the total cost of obesity? The cost of diabetes ? It is an enormous waste of resources.