Such things may necessarily be unknowable. If there are classes of observations that we are unable to make, or problems that we are unable to comprehend, its absolutely plausible that they would be cognitive blindspots.
In fact there's a whole theoretical strand in cognitive science / ontology that suggests this. We perceive and act only against a model of the world tuned for fitness rather than accuracy. i.e.: we are not perceiving objective reality at any scale, but rather a mental representation of it which is tailored to fitness. This is deeply unintuitive, but of course it would be since it relates to the limits on our ability to intuit.