If you're interested in projects taking advantage of this knowledge, the Daid's LADX Randomizer [0] is awesome. It includes a ton of assembly tweaks that makes the engine more flexible, and add many options to the game.
And Link’s Awakening Redux [1] is a good example of life-improvement game tweaks made using the disassembly.
[0] LADXR: https://daid.github.io/LADXR/ [1] Link’s Awakening Redux: https://github.com/ShadowOne333/Links-Awakening-Redux