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Comment by jkarni | Hacker News Reader

This is coming from David Sinclair, who claimed resveratrol was the fountain of youth (it wasn't, but he still managed to sell his resveratrol company for hundreds of millions), and pushed rather hard also on NAD/NMN despite only very preliminary and limited results (he also has interests in NMN companies, and has been involved in removing it from the supplement market in favor of that company's right to market it as a drug). More likely than a cure for aging, Sinclair just found another cure for too few cars in his garage.

https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-...

https://www.nutraingredients-usa.com/Article/2022/11/15/FDA-...

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He also says this in the article:

“ This is the first study showing that we can have precise control of the biological age of a complex animal; that we can drive it forwards and backwards at will”

And the paper doesn’t show that at all. The paper does not show them reversing the aging of anything.

I couldn't get access to the paper, but the abstract and the article both claimed they were able to reverse organ damage caused by the aging. Is that not backed up in the paper?

Idk why selling something you believe in disqualifies you as a scientist.

He’s also helped pioneer and make credible the entire field of aging research to reform people’s idea of how to look at aging.

Don’t be so cynical dude.

It's generally still not considered a credible field. Mostly hucksters and grifters.

He is a professor at Harvard - I imagine he wouldn't get to that role if the science didn't have some merit.

Where did he ever say that resveratol was the fountain of youth? Interviews I've seen with him seem more reasonable then I always hear people make him out to be.

NMN does have some promising results based on recent studies- what do you mean he pushed hard? Where did he actually do that?

Resveratrol is "as close to a miraculous molecule as you can find."

NAD+ “is the closest we’ve gotten to a fountain of youth.”

Both quoted in an excellent article on Sinclair:

https://www.bostonmagazine.com/health/2019/10/29/david-sincl...

>> He is a professor at Harvard - I imagine he wouldn't get to that role if the science didn't have some merit.

You should see what Huberman often shills and he's a prestigious professor as well.

Would also add that until recently - and by his own hand - Jordan Peterson was a professor at first Harvard, then the University of Toronto.

what exactly does Huberman shill? As far as I can tell, he has done an extemely commendable service bringing academic literature to the masses.

Don't know about Huberman but how did JP "shill" anything? Can you give a few examples of deceptive statements by him?

> Can you give a few examples of deceptive statements by him?

Joking, are we?

Spill the tea girlfriend, I'm sure you are right but we don't all follow or have even heard of him, why be coy.

He shills diet, sleep and exercise, and maybe circadian stuff. What are you referencing here? The ad sponsors?

Andrew Huberman does take and talk about certain medications and supplements which haven't yet been proven effective. However, he has always been completely clear about what the science does and does not say so that people can make up their own minds. He has also consistently been open and ethical about conflicts of interest.

https://hubermanlab.com/developing-a-rational-approach-to-su...

Who in the anti-aging space do HN users consider credible?

Without any doubt—The NIA Interventions Testing Program. They have 20 years of experience on effects of dietary interventions supporting longer lifespan.

https://www.nia.nih.gov/research/dab/interventions-testing-p...

Does anybody write articles on the stuff that is released from this org that lay people can understand?

There is Reason who runs a successful biotech company, and his corpus of writing at https://fightaging.org

His commentary on new papers in ageing is pretty good, in my opinion.

He has a good coverage of NIA ITP trials as well: https://duckduckgo.com/?q=site%3Afightaging.org+NIA&ia=web

Dr. Kaeberlein and Dr. Attia.

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